HIV Key Receptor Identified

Gamete Fusion: Key Protein Identified

Is there a common mechanism of eukaryotic sex? Two recent reports highlight an ancient and widely distributed protein that is key to gamete fusion and is a potential target for malaria vaccines.

Key Facts about Epidemiology of HIV/AIDS in Children Worldwide

Unfortunately, we do not know how many perinatally (Human Immunodeficiency Virus) HIV-infected pepole are living in contries today, while knowing these informations is necessary. UNAIDS reports that there are 3.4 million children under 15 years of age with HIV and 2 million adolescents between 10 and 19 years of age. Although the vast majority of children were perinatally infected, older childr...

New Anti - HIV Proteins Identified

Plant receptor kinases: systemin receptor identified.

P lant growth and development are regulated by intrinsic growth regulators, as well as by both beneficial and detrimental environmental cues. Hormonal, environmental, or pathogenic signals are mostly perceived by membrane-localized receptors that transduce those signals inside plant cells to activate programs directing growth, development, and defense responses. In the fully sequenced Arabidops...

CD4 Receptor is a Key Determinant of Divergent HIV-1 Sensing by Plasmacytoid Dendritic Cells

Plasmacytoid dendritic cells (pDC) are innate immune cells that sense viral nucleic acids through endosomal Toll-like receptor (TLR) 7/9 to produce type I interferon (IFN) and to differentiate into potent antigen presenting cells (APC). Engagement of TLR7/9 in early endosomes appears to trigger the IRF7 pathway for IFN production whereas engagement in lysosomes seems to trigger the NF-κB pathwa...